General aspects

1. Antimicrobial drug effects

2. Post antibiotic effect

3. Combined use of antibiotics

4. Factors affecting choice of antimicrobial agent

5. Drug resistance

Classification of antimicrobials

1. Cell wall synthesis inhibitors

a) Fosfomycin

b) Vancomycin

c) Cycloserine

d) Bacitracin

e) Beta- Lactams

– Penicillins

– Cephalosporins

– Carbapenems

– Monobactams

2. Antibiotics acting on cell membrane

a) Polymixins

b) Daptomycin

3. Protein synthesis inhibitors

a) Tetracyclines

b) Chloramphenicol

c) Macrolides

d) Clindamycin

e) Aminoglycosides

f) Lincosamides

g) Linezolid

h) Streptogramins

4. DNA Gyrase inhibitors

a) Quinolones

b) Flouroquinolones

5. Urinary antisceptics

a) Nitrofurantoin

b) Methanamine mandelate

c) Nalidixic acid

d) Phenazopyridine

6. Drugs affecting nucleic acids

a) DNA Gyrase inhibitors

b) RNA polymerase inhibitors

7. Antimetabolites

8. Drugs not affective against particular bacteria

9. Pseudomembranous colitis