MOLECULAR REARRANGEMENT NOTES FOR CLASS11/12 AND MSc/BSc Handwritten Notes PDF

CONTENTS

mechanistic treatment of nucleophilic, electrophilic and free-radical rearrangements.

Rearrangements reactions involving migration to electron deficient Carbon: Wagner-

Meerwein rearrangement, hydride shift (1,2-hydride shift, long range hydride shift), pinacolpinacolone

rearrangement, dienone-phenol rearrangement, acid catalyzed isomerization of

aromatic hydrocarbons, benzil-benzilic rearrangement, rearrangements involving diazomethane

and alkanes, Wolf rearrangement, migration of hetero atoms, rearrangement of aryl

hydroxylamines (Bamberger reaaarngement).

Rearrangements reactions involving migration to electron rich Carbon: Favorskii, Sommlet-

Hauser, Neber, Stevens and Wittig rearrangements.

Rearrangements reactions involving migration to electron deficient Nitrogen: Hoffmann,

Curtius, Schmidt, Lossen and Beckmann rearrangement.

Rearrangements reactions involving migration to electron deficient Oxygen: Bayer-Villiger

oxidation, hydroperoxide rearrangement and Dakin rearrangement.

AROMATIC REARRANGEMENTS: Migration around the aromatic nucleus – migration of

alkyl groups and halogens. Migration of group from the side chain to the nucleus –

rearrangement of aniline derivatives (N-haloacetanilides, Hofmann-Martius rearrangement,

phenylhydroxylamine, diazoamino compounds, N-nitroanilines, N-nitosoanilines).

Rearrangements involving migration from oxygen to aromatic ring – phenolic ethers, Fries,

Claisen rearrangements.