BIOINORGANIC CHEMISTRY HANDWRITTEN NOTES FOR MSc AND BSc

CONTENTS

Nitogen fixation – Biological nitrogen fixation: Nitrogenase enzyme, structure, N2 binding sites and mechanism of action.

Electron transfer proteins:

Metalloenzymes:

peroxidase and cytochrome p-450. Vitamin B12 and coenzymes: structure of corrin ring,

Applied bioinorganic chemistry:

Heavy metal ion toxicity: Hg, Pb, Cd, As toxic effects – mechanism of toxic effects. Heavy

metal toxicity treatment- chelation therapy: chelating agents for Hg, Pb, Cd, As toxicity. Metal

complexes as drugs: cis-plain as anticancer agent: mechanism of action and side effects; gold

complexes as antiarthritic drugs- chrysotherapy. Metal complexes in diagnosis – Gd complexes

in magnetic resonance imaging (MRI).